Brain manganese and the balance between essential roles and neurotoxicity [Molecular Bases of Disease]
Manganese (Mn) is an essential micronutrient required for the normal development of many organs, including the brain. Although its roles as a cofactor in several enzymes and in maintaining optimal physiology are well-known, the overall biological functions of Mn are rather poorly understood. Alterations in body Mn status are associated with altered neuronal physiology and cognition in humans, and either overexposure or (more rarely) insufficiency can cause neurological dysfunction. The resultant balancing act can be viewed as a hormetic U-shaped relationship for biological Mn status and optimal brain health, with changes in the brain leading to physiological effects throughout the body and vice versa. This review discusses Mn homeostasis, biomarkers, molecular mechanisms of cellular transport, and neuropathological changes associated with disruptions of Mn homeostasis, especially in its excess, and identifies gaps in our understanding of the molecular and biochemical mechanisms underlying Mn homeostasis and neurotoxicity.
Many Family Medicine Successful Interventions and Clinical Reviews for Common Illnesses
Family physician researchers continue to provide assistance to improve family medicine care. Commentaries on social determinants of health lead off this issue. Next, we have several papers on successful interventions by clinicians and/or patients to improve diabetes control, and then other provide information on other practice interventions that make a difference in overall care. Drug advertising continues to mislead. There is costly and nonproductive overuse of specific types of care. Herein is also a Scoping Review of possible indices for determining timely initiation of advance care planning. The issue’s clinical reviews on use of transgender care, cervical myelopathy, and inhaled steroids for chronic obstructive pulmonary disease are pertinent, thorough, and timely.
Many people face high risk of PTSD after being injured, research finds
A significant number of injury survivors experience post-traumatic stress disorder, and better screening practices could help connect them to mental health services.
Many Car Crash Deaths Involve Alcohol Levels Below Legal Limit: Study
Title: Many Car Crash Deaths Involve Alcohol Levels Below Legal Limit: Study
Category: Health News
Created: 3/16/2020 12:00:00 AM
Last Editorial Review: 3/17/2020 12:00:00 AM
Many Seniors Leave Hospital With New Disabilities
Title: Many Seniors Leave Hospital With New Disabilities
Category: Health News
Created: 3/2/2020 12:00:00 AM
Last Editorial Review: 3/3/2020 12:00:00 AM
Many With Dog Allergies Might Only Be Allergic to Male Dogs
Title: Many With Dog Allergies Might Only Be Allergic to Male Dogs
Category: Health News
Created: 1/7/2020 12:00:00 AM
Last Editorial Review: 1/8/2020 12:00:00 AM
I Want to Retire, But Just Can't Say Goodbye
Many doctors are considering retiring, but fear they'll miss the patient interaction, mental stimulation, and income. There are ways to have it all.
Many Seniors Think They See Better Than They Actually Do
Title: Many Seniors Think They See Better Than They Actually Do
Category: Health News
Created: 2/5/2020 12:00:00 AM
Last Editorial Review: 2/6/2020 12:00:00 AM
Many Americans in the Dark About Eye Health
Title: Many Americans in the Dark About Eye Health
Category: Health News
Created: 1/26/2020 12:00:00 AM
Last Editorial Review: 1/27/2020 12:00:00 AM
Many Smokers Switch to Vaping While Pregnant, But Safety Issues Remain
Title: Many Smokers Switch to Vaping While Pregnant, But Safety Issues Remain
Category: Health News
Created: 4/29/2019 12:00:00 AM
Last Editorial Review: 4/30/2019 12:00:00 AM
Many Cardiologists Ill-Equipped to Treat Heart Disease in Cancer Survivors
Title: Many Cardiologists Ill-Equipped to Treat Heart Disease in Cancer Survivors
Category: Health News
Created: 4/29/2019 12:00:00 AM
Last Editorial Review: 4/30/2019 12:00:00 AM
Many Women With Heart Disease Falling Short on Exercise
Title: Many Women With Heart Disease Falling Short on Exercise
Category: Health News
Created: 4/26/2019 12:00:00 AM
Last Editorial Review: 4/29/2019 12:00:00 AM
Many Manly Men Avoid Needed Health Care
Title: Many Manly Men Avoid Needed Health Care
Category: Health News
Created: 4/28/2016 12:00:00 AM
Last Editorial Review: 4/29/2016 12:00:00 AM
Many Pregnant Women Think E-Cigarettes 'Safer' Than Regular Cigarettes
Title: Many Pregnant Women Think E-Cigarettes 'Safer' Than Regular Cigarettes
Category: Health News
Created: 4/30/2015 12:00:00 AM
Last Editorial Review: 5/1/2015 12:00:00 AM
Many Ivy League Students Admit Using ADHD Drugs for Better Grades: Study
Title: Many Ivy League Students Admit Using ADHD Drugs for Better Grades: Study
Category: Health News
Created: 5/2/2014 12:36:00 PM
Last Editorial Review: 5/2/2014 12:00:00 AM
Many U.S. Teens Struggle With Extreme Fatigue: Survey
Title: Many U.S. Teens Struggle With Extreme Fatigue: Survey
Category: Health News
Created: 5/1/2013 12:35:00 PM
Last Editorial Review: 5/2/2013 12:00:00 AM
Many Stroke Patients Don't Call 911, Study Finds
Title: Many Stroke Patients Don't Call 911, Study Finds
Category: Health News
Created: 4/30/2013 10:35:00 AM
Last Editorial Review: 4/30/2013 12:00:00 AM
Many Asthmatic Kids Harmed by Secondhand Smoke: Study
Title: Many Asthmatic Kids Harmed by Secondhand Smoke: Study
Category: Health News
Created: 5/1/2012 10:05:00 AM
Last Editorial Review: 5/1/2012 12:00:00 AM
Many Diabetes Patients Wear the Wrong Shoes
Title: Many Diabetes Patients Wear the Wrong Shoes
Category: Health News
Created: 4/23/2011 11:00:00 AM
Last Editorial Review: 4/25/2011 12:00:00 AM
Many in U.S. Have at Least 1 Heart Risk Factor
Title: Many in U.S. Have at Least 1 Heart Risk Factor
Category: Health News
Created: 4/27/2010 10:36:00 AM
Last Editorial Review: 4/27/2010 10:36:05 AM
Many Adults Delay Getting Help for Eating Disorders
Title: Many Adults Delay Getting Help for Eating Disorders
Category: Health News
Created: 4/21/2020 12:00:00 AM
Last Editorial Review: 4/22/2020 12:00:00 AM
Egyptian pyramids really were aligned with the compass points
Many ancient monuments are claimed to be aligned to celestial phenomena, but we now have the first statistical evidence this is the case for the Egyptian pyramids
Why countries should start weekly covid-19 testing for key workers
Many countries are focusing coronavirus testing on people who have covid-19 symptoms. But regularly testing all essential workers would have more of an impact
Coronavirus: What does evidence say about schools reopening?
Many studies suggest coronavirus has low transmission rates among children, but there are still risks to reopening schools that were closed due to social distancing policies
Can virtual therapy help us cope with the coronavirus lockdown?
Many people are turning to virtual therapy and mental health apps to cope with the stress of the coronavirus pandemic, but they may not be as helpful as talking face to face
Egyptian pyramids really were aligned with the compass points
Many ancient monuments are claimed to be aligned to celestial phenomena, but we now have the first statistical evidence this is the case for the Egyptian pyramids
The science of pastry: Master a shortcrust and make a rhubarb tart
Many people feel intimidated by the prospect of making pastry, says Sam Wong, but a little understanding can go a long way to successfully making this beautiful rhubarb tart
Why the human race may be less gullible than you think
Many classic psychology experiments have found humans to be pretty gullible. But book Not Born Yesterday argues that such a trait runs against the logic of natural selection
Mangoes off the menu for lonely primates, as Kiev zoo struggles in lockdown
Mykhailo Pinchuk takes a short walk around his empty zoo, greeting some animals with a stroke and a morsel of food.
Dinosaur extinction lines up closely with timing of volcanic eruptions
Many people assume an asteroid triggered the mass extinction that killed the dinosaurs, but geologists say massive volcanic eruptions occurred at the same time
Orangutans and other great apes under threat from covid-19 pandemic
Many great ape species are already in a precarious situation because of their dwindling numbers. Now they may also be at risk from the coronavirus pandemic
Man raised alongside chimps says it should never happen again
Nick Lehane's performance piece, Chimpanzee, in London for the first time, reveals how tragedy stalked the amazing achievement of raising chimps in human families
Managing IP recognizes 33 Dentons' Intellectual Property lawyers as 2020/21 IP Stars
The 2020/ 21 edition of IP Stars, the leading specialist guide to IP firms and practitioners worldwide developed by Managing IP, has recognized 33 of Dentons’ global Intellectual Property practitioners for their outstanding experience in contentious and non-contentious IP advice in the areas of trade mark and patent work.
Managing Climate Adaptive Water Resources in the Aral Sea Basin in Uzbekistan
ADB is proposing a project to deliver climate adaptive solutions for water resources management and modernize outdated irrigation and drainage systems within the Amu Darya and selected reaches of the Zarafshan irrigation system.
Man killed, another wounded in Gulshan shootout
A man was killed and another wounded during a clash within the Gulshan-e-Iqbal police station’s limits on Friday.Police said the incident took place when the two men exchanged fire near Kamran Market in Gulshan-e-Iqbal Block 1. As a result, both were wounded and taken to Jinnah Postgraduate...
Two die, three injured in Kohistan road accident
MANSEHRA: Two persons were killed and three others sustained injuries when a pickup vehicle plunged into a ravine in Shahshi Gigal area of Lower Kohistan on Friday.The vehicle was on way to Kokai...
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Covid-19 responses increasing vulnerability of the disabled
Many individuals with disabilities have been hard hit due to loss of income.
Man attacks guards at Chamber of Deputies entrance during active session
Prague Daily Monitor
A 31 year-old Czech speaking man approached the entrance to the gate armed with two knives yesterday. When police became aware of the man being armed, the man threatened the police, demanding to be let into the building. Police apprehended the suspect, nobody was injured during the incident. The suspect faces up to four years in prison for violence against an official.
JUI-F leader for proper burial of corona victims
MANSEHRA: The Jamiat Ulema-i-Islam-Fazl leader Mufti Kifayatullah, who received a warm welcome by his party workers on his release, has reiterated his earlier stance of a ‘respectable’ burial of patients died of Covid-19.“I am not afraid of jails and would never allow police and...
Two die, three injured in Kohistan road accident
MANSEHRA: Two persons were killed and three others sustained injuries when a pickup vehicle plunged into a ravine in Shahshi Gigal area of Lower Kohistan on Friday.The vehicle was on way to Kokai from Gijal when it met to accident while negotiating a sharp turn.The local rushed to scene and...
Man who drowned in Sea of Galilee tests positive for coronavirus
The man, who drowned on Friday in the Sea of Galilee, tested positive for coronavirus soon after and was moved in critical condition to the coronavirus care unit in the hospital.
Many policy differences to tackle in government talks
Fianna Fáil, Fine Gael and the Green Party are meeting in the Department of Agriculture to try to resolve their significant differences on housing, public transport and the environment, writes Sandra Hurley.
Man Held for Killing Police Officer Using Hand Grenade
[Dalsan Radio] Security officers have arrested a man linked with the hand grenade attack in which a police officer was killed.
Man accused of killing his wife, two children, arrested
It’s alleged that he strangled his wife and two sons and fled
Looking for the right words during the pandemic
Many English-speaking leaders have been using war terminology when discussing the coronavirus, but politicians in Japan have their own way of speaking to the ...
Forget about anime production delays by streaming these classics
Many anime releases have been delayed indefinitely due to the COVID-19 outbreak, but in the meantime, with their vast libraries of anime films and series, ...
Lagarde can’t solve the COVID-19 crisis
Managing the COVID-19 crisis goes way beyond the powers of central banks.
Man wanted for 4 murders arrested after 6 years on the run
A man wanted in connection with the murder of four people in Ayutthaya was arrested in Suphan Buri on Saturday, six years after fleeing arrest.
Inbound flights to Manila set to resume
MANILA: Manila’s international airport will allow international charter and commercial flights to resume arriving on designated days, beginning from Monday.